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Cantargia AB via Public / R Cantargia rapporterar att första

08.10.2020 - STOCKHOLM, Oct. 8, 2020 /PRNewswire/ - Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 … Etiketter:Bukspottkörtelcancer, CAN04, CANFOUR, Cantargia, Icke-småcellig lungcancer. Extensionsdelen har designats för att ge ytterligare information som kompletterar den primära kohorten av 31 patienter. Nio av dessa patienter behandlas fortfarande vilket fortlöpande ger … 2021-03-31 2021-03-10 2019-07-05 Cantargia presents clinical data from its ongoing CANFOUR trial at ESMO Cantargia AB (publ) today announced that interim results from its clinical Phase I/II trial of lead candidate CAN04 (nidanilimab) will be presented in a poster presentation at the ESMO Congress 2018 in … Behandling på tværs af kræftsygdomme, Brystkræft, Bugspytkirtelkræft, Endetarmskræft, Lungekræft, ikke småcellet, Tyktarmskræft. Stadie 3, Stadie 4 (stadiet beskriver, hvor fremskreden sygdommen er). I forsøget undersøger lægerne virkningen og bivirkningerne ved det nye forsøgslægemiddel CAN04.

Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa extension cohort Wed, Feb 10, 2021 13:30 CET. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and chemotherapy. STOCKHOLM, Oct. 2, 2020 /PRNewswire/ -- Cantargia AB today announced that the first patient has started treatment with the antibody CAN04 and pembrolizumab in a phase I clinical trial in USA. The trial continues according to the clinical protocol and will include up to 18 patients. Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). Cantargias antikropp CAN04 (nidanilimab) studeras i en öppen tre-armad fas IIa klinisk studie, CANFOUR. I studien undersöks CAN04 som monoterapi eller i kombinationer med cellgifter i patienter med icke-småcellig lungcancer (NSCLC) eller bukspottkörtelcancer (PDAC). In the CANFOUR trial, treatment using Cantargia’s proprietary antibody CAN04, directed towards the molecular target IL1RAP, is investigated in patients with cancer.

Styrelsen för Cantargia AB (publ) har, med stöd av bolagsstämmans bemyndigande, beslutat att genomföra en riktad nyemission om cirka 106 miljoner kronor. Likviden möjliggör en utökad satsning på bolagets huvudprojekt CAN04 (nidanilimab) med en ny klinisk studie i USA och en expansion av den mest lovande subgruppen patienter i den pågående kliniska studien CANFOUR.

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So far, 15 patients have received therapy in the phase I safety part of the study, and generally the immuno-oncology antibody CAN04, targeting IL1RAP, has been well tolerated. Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa extension cohort Wed, Feb 10, 2021 13:30 CET. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and chemotherapy. STOCKHOLM, Oct. 2, 2020 /PRNewswire/ -- Cantargia AB today announced that the first patient has started treatment with the antibody CAN04 and pembrolizumab in a phase I clinical trial in USA. The trial continues according to the clinical protocol and will include up to 18 patients. Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP).

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A decrease in the biomarkers IL-6 and CRP. Stable disease in 43 per cent of patients. The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on Cantargia is a clinical-stage biotechnology company based in Sweden, established in 2009 and listed on the Nasdaq Stockholm main market. It is developing two assets against IL1RAP, CAN04 and CAN10. CAN04 is being studied in a Phase IIa clinical trial, CANFOUR, in solid tumours focusing on NSCLC and pancreatic cancer.

The outcome will, in our view, represent a major valuation trigger for the share and potentially also lead to a partnership deal. I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel.
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Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. I CANFOUR undersöks behandling med antikroppen CAN04 v Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 and chemotherapy have started treatment. In the interim data set, no unexpected side effects have been reported, but notably fatigue and neuropathy were less common than reported from chemotherapy, while neutropenia was more common. I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel. En interimsanalys av 20 patienter i oktober 2020 visade på s.k. respons i 40% av patienterna (inkluderande 2 patienter som inte behandlats tillräckligt länge för en andra, bekräftande CT-scan), vilket är högre än historiska CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR.

21 AUG 2020. Commissioned Research: CANFOUR progressing according to plan. In addition, early signs of efficacy during treatment with CAN04 will be investigated.. Clinical Trials Registry. ICH GCP. Acronym, CANFOUR. Study Design Info.
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Cantargia develops antibody-based pharmaceuticals against interleukin-1 receptor accessory protein (IL1RAP). Cantargias antikropp CAN04 (nidanilimab) studeras i en öppen tre-armad fas IIa klinisk studie, CANFOUR. I studien undersöks CAN04 som monoterapi eller i kombinationer med cellgifter i patienter med icke-småcellig lungcancer (NSCLC) eller bukspottkörtelcancer (PDAC). In the CANFOUR trial, treatment using Cantargia’s proprietary antibody CAN04, directed towards the molecular target IL1RAP, is investigated in patients with cancer.

CanFour är en Fas-1 studie med en ny läkemedel Can04. Can04 är en antikropp som har IL-1RAP som mål. Verkningsmekanism tros vara en minskning av inflammation i tumörens´mikromiljön + ADCC + stimulering av NK celler. Studie population är Bukspottskörtelcancer och Icke småcellig lungcancer. Under 2020 planerar Cantargia starta en ny studie med CAN04. I den här studien kommer CAN04 kombineras med en s.k. checkpoint inhibitor, dvs den typ av immunterapi som etablerat sig som en del av standardbehandlingen inom t.ex.
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Cantargia: Stärkta i vår uppfattning om CAN04 - Finwire

Summary CANFOUR CAN04CLIN002. Proof of concept . Open phase I/IIa study to assess safety and signs of efficay during treatment with CAN04. Phase I In the CANFOUR part examining PDAC, 9 patients in the first cohort of 31 are currently on treatment with CAN04 in combination with gemcitabine and nab-paclitaxel. An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control[1]. Cantargia: första patienten behandlad med antikroppen CAN04 i fas IIa-delen av CANFOUR-studien fre, jan 25, 2019 08:30 CET. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighe Cantargia: Fas I säkerhetsutvärderingsdelen av CANFOUR studien med antikroppen CAN04 är genomförd och fas IIa-delen initieras fre, dec 07, 2018 15:30 CET. Cantargia AB (publ) meddelar idag att samtliga patienter i fas I-delen av den kliniska prövningen CANFOUR har fullföljt den formella säkerhetsutvärderingsdelen av studien.